Dr. James L. Campbell Jr., MD discusses Skin Cancer Melanoma Biopsy and Histology. See more at www.dermnet.com PLEASE RATE AND COMMENT!!! Biopsy and histology Biopsy all suspicious lesions. Palpate the regional nodes prior to biopsy and document the findings. The only ""perfect"" biopsy technique is complete excision of the entire lesion into subcutaneous fat. This allows for accurate measurement of the thickness of the lesion in millimeters referred to as the Breslow
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